Macrophage M1/M2 polarization

被引：2308

作者：

Chen Yunna ^{[1
,2
,3
]}

Hu Mengru ^{[1
,2
,3
]}

Wang Lei ^{[1
,2
,3
,4
]}

Chen Weidong ^{[1
,2
,3
,4
]}

机构：

[1] Anhui Univ Chinese Med, Coll Pharm, Hefei 230012, Peoples R China

[2] Anhui Prov Key Lab Chinese Med Formula, Hefei 230012, Anhui, Peoples R China

[3] Anhui Acad Chinese Med, Inst Pharmaceut, Hefei 230012, Anhui, Peoples R China

[4] Educ Off Anhui Prov, Engn Technol Res Ctr Modernized Pharmaceut, Hefei 230012, Anhui, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2020年 / 877卷

基金：

中国国家自然科学基金;

关键词：

Macrophage polarization; Tumor microenvironment; Nanocarriers; Nuclear receptor PPAR gamma; NF-kappa B; SOLUBILIZED EXTRACELLULAR-MATRIX; TUMOR-ASSOCIATED MACROPHAGES; ALTERNATIVE ACTIVATION; IN-VITRO; INFLAMMATORY RESPONSE; NLRP3; INFLAMMASOME; BIOACTIVE GLASSES; MULTIFACETED ROLE; NANOPARTICLES; CANCER;

D O I：

10.1016/j.ejphar.2020.173090

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Macrophages can be affected by a variety of factors to change their phenotype and thus affect their function. Activated macrophages are usually divided into two categories, M1-like macrophages and M2-like macrophages. Both M1 macrophages and M2 macrophages are closely related to inflammatory responses, among which M1 macrophages are mainly involved in pro-inflammatory responses and M2 macrophages are mainly involved in anti-inflammatory responses. Improving the inflammatory environment by modulating the activation state of macrophages is an effective method for the treatment of diseases. In this review, we analyzed the mechanism of macrophage polarization from the tumor microenvironment, nanocarriers, nuclear receptor PPAR gamma, phagocytosis, NF-kappa B signaling pathways, and other pathways.

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页数：9

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