The correlation between transepidermal water loss and percutaneous absorption: An overview

被引:107
作者
Levin, J [1 ]
Maibach, H [1 ]
机构
[1] Univ Calif San Francisco, Dept Dermatol, Sch Med, San Francisco, CA 94143 USA
关键词
percutaneous absorption; transepidermal water loss; skin permeability and toxicity;
D O I
10.1016/j.jconrel.2004.11.035
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Independently, both transepidermal water loss (TEWL) and percutaneous absorption measurements accurately gauge stratum corneum skin water barrier integrity. Both TEWL and percutaneous absorption rates increase when the integrity of the SC barrier is compromised. Experiments to discern a quantitative and/or qualitative correlation between the two indicators have resulted in controversy. This paper reviews some major studies investigating this correlation. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:291 / 299
页数:9
相关论文
共 32 条
[1]   TRANSEPIDERMAL WATER-LOSS AND ABSORPTION OF HYDROCORTISONE IN WIDESPREAD DERMATITIS [J].
AALTOKORTE, K ;
TURPEINEN, M .
BRITISH JOURNAL OF DERMATOLOGY, 1993, 128 (06) :633-635
[2]  
[Anonymous], 1991, IN VITRO PERCUTANEOU
[3]  
BRONAUGH R, 1983, J PHARM SCI, V73, P1255
[4]   METHODS FOR INVITRO PERCUTANEOUS-ABSORPTION STUDIES .6. PREPARATION OF THE BARRIER LAYER [J].
BRONAUGH, RL ;
STEWART, RF .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (05) :487-491
[5]   METHODS FOR INVITRO PERCUTANEOUS-ABSORPTION STUDIES .1. COMPARISON WITH INVIVO RESULTS [J].
BRONAUGH, RL ;
STEWART, RF ;
CONGDON, ER ;
GILES, AL .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 62 (03) :474-480
[6]   DIFFERENTIAL RATES OF PERCUTANEOUS-ABSORPTION THROUGH THE ECZEMATOUS AND NORMAL SKIN OF A MONKEY [J].
BRONAUGH, RL ;
WEINGARTEN, DP ;
LOWE, NJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1986, 87 (04) :451-453
[7]   METHODS FOR INVITRO PERCUTANEOUS-ABSORPTION STUDIES .2. ANIMAL-MODELS FOR HUMAN-SKIN [J].
BRONAUGH, RL ;
STEWART, RF ;
CONGDON, ER .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 62 (03) :481-488
[8]   METHODS FOR INVITRO PERCUTANEOUS-ABSORPTION STUDIES .5. PERMEATION THROUGH DAMAGED SKIN [J].
BRONAUGH, RL ;
STEWART, RF .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1985, 74 (10) :1062-1066
[9]   VEHICLE EFFECTS ON PERCUTANEOUS-ABSORPTION - INVIVO AND INVITRO COMPARISONS WITH HUMAN-SKIN [J].
BRONAUGH, RL ;
FRANZ, TJ .
BRITISH JOURNAL OF DERMATOLOGY, 1986, 115 (01) :1-11
[10]   Transepidermal water loss does not correlate with skin barrier function in vitro [J].
Chilcott, RP ;
Dalton, CH ;
Emmanuel, AJ ;
Allen, CE ;
Bradley, ST .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 118 (05) :871-875