The correlation between transepidermal water loss and percutaneous absorption: An overview

被引：107

作者：

Levin, J ^{[1
]}

Maibach, H ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, Sch Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2005年 / 103卷 / 02期

关键词：

percutaneous absorption; transepidermal water loss; skin permeability and toxicity;

D O I：

10.1016/j.jconrel.2004.11.035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Independently, both transepidermal water loss (TEWL) and percutaneous absorption measurements accurately gauge stratum corneum skin water barrier integrity. Both TEWL and percutaneous absorption rates increase when the integrity of the SC barrier is compromised. Experiments to discern a quantitative and/or qualitative correlation between the two indicators have resulted in controversy. This paper reviews some major studies investigating this correlation. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：291 / 299

页数：9