Antioxidant quinonemethide triterpenes from Salacia campestris

被引:37
作者
Carvalho, PRF [1 ]
Silva, DHS [1 ]
Bolzani, VS [1 ]
Furlan, M [1 ]
机构
[1] Univ Estadual Paulista, Inst Quim, BR-14801900 Araraquara, SP, Brazil
关键词
D O I
10.1002/cbdv.200590016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new quinonemethide triterpene named as salacin, has been isolated from the root bark of Salacia campestris in addition to the known pristimerin, maytenin, 20 alpha-hydroxymaytenin, and netzahualcoyene. Salacin was identified on the basis of NMR-spectral and mass spectrometric analysis. The free-radical scavenging activities of the quinonemethide triterpenes salacin (1), pristimerin (2), maytenin (3), 20a-hydroxymaytenin (4), and netzahualcoyene (5) towards DPPH have been evaluated and showed absorbance variation (AA) of 19, 20, 39, 28, 55, and 10%, respectively, having rutin (74% at 50 pm) and BHT (7% at 50 mu M) as standard compounds.
引用
收藏
页码:367 / 372
页数:6
相关论文
共 24 条
[1]  
BHATNAGAR S. S., 1951, JOUR SCI AND INDUST RES [INDIA], V10B, P56
[2]   ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].
BLOIS, MS .
NATURE, 1958, 181 (4617) :1199-1200
[3]  
Bondet V, 1997, FOOD SCI TECHNOL-LEB, V30, P609
[4]   CHEMICAL STUDIES ON MEXICAN PLANTS USED IN TRADITIONAL MEDICINE .11. FRIEDELANES AND TRITERPENOID QUINONE METHIDES FROM HIPPOCRATEA-EXCELSA [J].
CALZADA, F ;
MATA, R ;
LOPEZ, R ;
LINARES, E ;
BYE, R ;
BARRETO, VM ;
DELRIO, F .
PLANTA MEDICA, 1991, 57 (02) :194-195
[5]   Antioxidant flavan-3-ols and flavonol glycosides from Maytenus aquifolium [J].
Corsino, J ;
Silva, DHS ;
Zanoni, MVB ;
Bolzani, VDS ;
França, SC ;
Pereira, AMS ;
Furlan, M .
PHYTOTHERAPY RESEARCH, 2003, 17 (08) :913-916
[6]   Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestris [J].
Corsino, J ;
de Carvalho, PRF ;
Kato, MJ ;
Latorre, LR ;
Oliveira, OMMF ;
Araújo, AR ;
Bolzani, VD ;
França, SC ;
Pereira, AMS ;
Furlan, M .
PHYTOCHEMISTRY, 2000, 55 (07) :741-748
[7]  
de Lima O G, 1971, Rev Inst Antibiot (Recife), V11, P35
[8]   Biogenetically important quinonemethides and other triterpenoid constituents of Salacia reticulata [J].
Dhanabalasingham, B ;
Karunaratne, V ;
Tezuka, Y ;
Kikuchi, T ;
Gunatilaka, AAL .
PHYTOCHEMISTRY, 1996, 42 (05) :1377-1385
[9]  
FERNANDO HC, 1989, TETRAHEDRON, V45, P5867
[10]   Novel quinone methides from Salacia kraussii with in vitro antimalarial activity [J].
Figueiredo, JN ;
Räz, B ;
Séquin, U .
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (06) :718-723