Molecular prognostics in colorectal cancer

被引：40

作者：

Kahlenberg, MS

Sullivan, JM

Witmer, DD

Petrelli, NJ

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Surg, Div Surg Oncol, San Antonio, TX 78229 USA

[2] Helen F Graham Canc Ctr, Newark, DE 19713 USA

来源：

SURGICAL ONCOLOGY-OXFORD | 2003年 / 12卷 / 03期

关键词：

colorectal cancer; prognostics; molecular markers;

D O I：

10.1016/S0960-7404(03)00006-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Conventional staging of colorectal cancer does not account for the marked variability in outcome that exists within each stage. Certain populations of patients with early recurrence, resistance to chemotherapy and decreased survival cannot be predicted utilizing common histopathologic criteria. As the molecular mechanisms underlying colorectal carcinogenesis are elucidated, putative molecular prognostic factors are identified. A comprehensive review of various molecular markers and their roles as prognostic factors in colorectal cancer is presented. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：173 / 186

页数：14

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