On-line chemiluminescence determination of mitoxantrone by capillary electrophoresis

被引：26

作者：

Han, Suqin ^{[1
]}

Wang, Huili ^{[1
]}

机构：

[1] Shanxi Normal Univ, Sch Chem & Mat Sci, Linfen 041004, Shanxi, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2010年 / 878卷 / 28期

基金：

中国国家自然科学基金;

关键词：

Mitoxantrone; Capillary electrophoresis; Chemiluminescence; Human urine; Human plasma; FLOW-INJECTION ANALYSIS;

D O I：

10.1016/j.jchromb.2010.08.006

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel capillary electrophoresis (CE) with chemiluminescence (CL) detection method for the determination of mitoxantrone (MTX) has been developed, which based on the CL reaction of potassium ferricyanide with luminol in sodium hydroxide medium sensitized by MTX. Under optimum analytical conditions, MTX is determined over the range of 7.0 x 10(-8)-1.0 x 10(-6) M with a detection limit of 1.0 x 10(-8) M. The relative standard deviation (RSD) was 3.7%, 2.6% and 3.0% for 7.0 x 10(-8), 5.0 x 10(-7) and 1.0 x 10(-6) M MTX (n = 11), respectively. In laboratory-built CE-CL apparatus, the proposed method has been applied to determination of MIX in commercial drug and spiked in human urine and plasma with satisfactory results. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：2901 / 2904

页数：4

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