Synthesis of 2',3'-fused (3.3.0) gamma-butyrolactone-nucleosides and coupling with amino-nucleosides to give amide-linked nucleotide-dimer analogues

被引：26

作者：

Robins, MJ ^{[1
]}

Sarker, S ^{[1
]}

Xie, MQ ^{[1
]}

Zhang, WJ ^{[1
]}

Peterson, MA ^{[1
]}

机构：

[1] BRIGHAM YOUNG UNIV,DEPT CHEM & BIOCHEM,PROVO,UT 84602

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 23期

关键词：

D O I：

10.1016/0040-4039(96)00715-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective hydrogenation of Wittig products obtained readily (via the 3'-ketones) from 2',5'-bis-O-(tert-butyldimethylsilyl)nucleosides provides efficient access to 2',3'-fused gamma-butyrolactone-nucleosides that can be coupled with 5'-amino-nucleosides (2-hydroxypyridine catalysis) to give amide-linked nucleotide-dimer analogues. (C) 1996 Elsevier Science Ltd

引用

页码：3921 / 3924

页数：4

共 20 条

[1]

BEYERMAN HC, 1963, P CHEM SOC LONDON, P266

[2]

COHEN JS, 1989, OLIGODEOXYNUCLEOTIDE

[3]

CROOKE S.T., 1993, ANTISENSE RES APPL

[4] CHARACTERIZATION OF FULLY 2'-MODIFIED OLIGORIBONUCLEOTIDE HETERODUPLEX AND HOMODUPLEX HYBRIDIZATION AND NUCLEASE SENSITIVITY [J].