SYNTHESIS AND HYBRIDIZATION PROPERTIES OF AMIDE-LINKED THYMIDINE DIMERS INCORPORATED INTO OLIGODEOXYNUCLEOTIDES

被引：68

作者：

IDZIAK, I ^{[1
]}

JUST, G ^{[1
]}

DAMHA, MJ ^{[1
]}

GIANNARIS, PA ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL H3A 2K6,QUEBEC,CANADA

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)73923-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thymidine dimers, connected by amide or N-methyl amide linkages, have been prepared. The dimers have each been incorporated three times into normal strands of DNA by solid phase synthesis. Thermal denaturation studies indicated that these modifications caused little or no destabilization of the DNA:RNA duplex.

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页码：5417 / 5420

页数：4

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