Asymmetric synthesis of (S)-vigabatrin® and (S)-dihydrokavain via cobalt catalyzed hydrolytic kinetic resolution of epoxides

被引：15

作者：

Raj, I. Victor Paul ^{[1
]}

Sudalai, A. ^{[1
]}

机构：

[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 16期

关键词：

D O I：

10.1016/j.tetlet.2008.02.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise route to the asymmetric synthesis of (S)-vigabatrin(R) and (S)-dihydrokavain has been described using Co-catalyzed hydrolytic kinetic resolution of racemic epoxides and regiospecific opening of terminal epoxides with dimethylsulfonium methylide as the key steps. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2646 / 2648

页数：3

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