Determination of water concentration in brain tissue by Raman spectroscopy

被引：74

作者：

Wolthuis, R

van Aken, M

Fountas, K

Robinson, JS

Bruining, HA

Puppels, GJ

机构：

[1] Erasmus Univ, Dept Gen Surg 10M, Lab Intens Care Res & Opt Spect, NL-3015 GD Rotterdam, Netherlands

[2] Univ Rotterdam Hosp Dijzigt, NL-3015 GD Rotterdam, Netherlands

[3] Inst Neurol Cent Georgia, Macon, GA 31201 USA

来源：

ANALYTICAL CHEMISTRY | 2001年 / 73卷 / 16期

关键词：

D O I：

10.1021/ac0101306

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Brain edema is one of the most common morbidity factors in patients with intracranial neoplasms and cerebrovascular pathology. Monitoring of intracranial pressure gives only an indirect and global measure of brain swelling. We have made an assessment of the applicability of Raman spectroscopy as an alternative method for assessing brain edema, which measures the water concentration in the tissue directly. Partial least-squares models were developed on the basis of Raman spectra measured in the 2600-3800-cm(-1) region, which predict the water fraction of brain tissue in the 0.75-0.95 range, with an accuracy better than 0.01.

引用

页码：3915 / 3920

页数：6

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