Neurotrophin-4: The odd one out in the neurotrophin family

被引：62

作者：

Ibanez, CF

机构：

[1] Department of Medical Biochemistry and Biophysics, Laboratory of Molecular Neurobiology, Karolinska Institute

来源：

NEUROCHEMICAL RESEARCH | 1996年 / 21卷 / 07期

关键词：

development; muscle; nervous system; nerve growth factor; site-directed mutagenesis;

D O I：

10.1007/BF02532301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotrophin-4 (NT-4) is a member of a family of neurotrophic factors, the neurotrophins, that control survival and differentiation of vertebrate neurons (2-4). Besides being the most recently discovered neurotrophin in mammals, and the least well understood, several aspects distinguish NT-4 from other members of the neurotrophin family. It is the most divergent member and, in contrast to the other neurotrophins, its expression is ubiquitous and appears to be less influenced by environmental signals. NT-4 seems to have the unique requirement of binding to the low-affinity neurotrophin receptor (p75(LNGFR)) for efficient signalling and retrograde transport in neurons. Moreover, while all other neurotrophin knock-outs have proven lethal during early postnatal development, mice deficient in NT-4 have so far only shown minor cellular deficits and develop normally to adulthood. Is NT-4 a recent addition to the neurotrophic factor repertoire in search of a crucial function, or is it an evolutionary relic, a kind of wisdom tooth of the neurotrophin family?

引用

页码：787 / 793

页数：7

共 49 条

[1]

ADAMS MD, 1995, NATURE, V377, P3

[2] THE NEUROTROPHINS NT-4/5 AND BDNF AUGMENT SEROTONIN, DOPAMINE, AND GABAERGIC SYSTEMS DURING BEHAVIORALLY EFFECTIVE INFUSIONS TO THE SUBSTANTIA-NIGRA [J].

ALTAR, CA ;

BOYLAN, CB ;

FRITSCHE, M ;

JACKSON, C ;

HYMAN, C ;

LINDSAY, RM .

EXPERIMENTAL NEUROLOGY, 1994, 130 (01) :31-40

[3] IN-SITU HYBRIDIZATION OF TRKB AND TRKC RECEPTOR MESSENGER-RNA IN RAT FOREBRAIN AND ASSOCIATION WITH HIGH-AFFINITY BINDING OF [I-125] BDNF, [I-125] NT-4/5 AND [I-125] NT-3 [J].

ALTAR, CA ;

SIUCIAK, JA ;

WRIGHT, P ;

IP, NY ;

LINDSAY, RM ;

WIEGAND, SJ .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (09) :1389-1405

[4] NEUROTROPHIN-4 SELECTIVELY PROMOTES SURVIVAL OF STRIATAL NEURONS IN ORGANOTYPIC SLICE CULTURE [J].

ARDELT, AA ;

FLARIS, NA ;

ROTH, KA .

BRAIN RESEARCH, 1994, 647 (02) :340-344

[5]

ARENAS E, 1996, IN PRESS EUR J NEURO

[6] TROPHIC FACTORS AND NEURONAL SURVIVAL [J].

BARDE, YA .

NEURON, 1989, 2 (06) :1525-1534

[7]

BARDE YA, 1994, J NEUROBIOL, V25

[8] NEUROTROPHIN-5 - A NOVEL NEUROTROPHIC FACTOR THAT ACTIVATES TRK AND TRKB [J].

BERKEMEIER, LR ;

WINSLOW, JW ;

KAPLAN, DR ;

NIKOLICS, K ;

GOEDDEL, DV ;

ROSENTHAL, A .

NEURON, 1991, 7 (05) :857-866

[9] HUMAN CHROMOSOME-19 CONTAINS THE NEUROTROPHIN-5 GENE LOCUS AND 3 RELATED GENES THAT MAY ENCODE NOVEL ACIDIC NEUROTROPHINS [J].

BERKEMEIER, LR ;

OZCELIK, T ;

FRANCKE, U ;

ROSENTHAL, A .

SOMATIC CELL AND MOLECULAR GENETICS, 1992, 18 (03) :233-245

[10] INHIBITION OF OCULAR DOMINANCE COLUMN FORMATION BY INFUSION OF NT-4/5 OR BDNF [J].

CABELLI, RJ ;

HOHN, A ;

SHATZ, CJ .

SCIENCE, 1995, 267 (5204) :1662-1666

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