Competence modulation by the NADH oxidase of Streptococcus pneumoniae involves signal transduction

Oxygen controls competence development in Streptococcus pneumoniae. Oxygen signaling involves the two-component signal transduction systems CiaRH and ComDE and the competence-stimulating peptide encoded by comC and processed by ComAB, We found that NADH oxidase (Nox) was required for optimal competence, Transcriptional analysis and genetic dissection showed that Nor was involved in post-transcriptional activation of the response regulator ComE and in the transcriptional control of ciaRH and comCDE. Thus, in S. pneumoniae, Nor, with O-2 as its secondary substrate, is part of the O-2-signaling pathway.