Meningococcal A vaccination response is enhanced by acute stress in men

被引:54
作者
Edwards, Kate M. [2 ]
Burns, Victoria E. [1 ]
Adkins, Alison E. [3 ]
Carroll, Douglas [1 ]
Drayson, Mark [3 ]
Ring, Christopher [1 ]
机构
[1] Univ Birmingham, Sch Sport & Exercise Sci, Edgbaston B15 2TT, England
[2] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[3] Univ Birmingham, Dept Clin Immunol, Birmingham B15 2TT, W Midlands, England
来源
PSYCHOSOMATIC MEDICINE | 2008年 / 70卷 / 02期
关键词
acute stress; exercise; adjuvants; meningococcal vaccination;
D O I
10.1097/PSY.0b013e318164232e
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To determine if acute stress experienced at the time of antigenic challenge augments the subsequent immune response. Methods: Sixty healthy young adults were randomized to exercise (n = 20), mental stress (n = 20) or control (n = 20) before meningococcal A+C vaccination. Antibody concentration was measured by microsphere-based antibody quantification assay at prevaccination, 4 and 20 weeks post vaccination. Results: Meningococcal serogroup A antibody responses were enhanced by exercise and mental stress in men but not women (F(2,51) = 4.00, p = .02, eta(2) = 0.135). Conclusions: Stress-induced immune enhancement has now been demonstrated in the antibody response to thymus-indepen dent as well as thymus-dependent vaccines. These findings indicate that this effect is not specific to T-cell involvement.
引用
收藏
页码:147 / 151
页数:5
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