Utility of gallium-67 scintigraphy in low-grade non-Hodgkin's lymphoma

Purpose: Low-grade non-Hodgkin's lymphoma (LGNHL) has traditionally been considered non-gallium-avid. The sensitivity oi: gallium 67 (Ga-67) seipttigrophy when using modern equipment and techniques in patients with LGNHL was investigated. Materials and Methods: Fifty-seven consecutive patients with LGNHL underwent Ga-67 scintigraphy at initial presentation (n = 40), when rumor progression occurred during treatment (n = 3), and at suspected disease recurrence after continuous clinical remission (CCR) (n = 14). Planer and tomographic images were obtained with either a very large field-of-view or a dual-head digital camera. Of 45 patients with Ga-avid LGNHL, 30 underwent 93 follow-up scans (one to six studies per patient). Scan findings were correlated with clinical and computed tomographic (CT) findings and with patient outcomes. Results: Ga-67 scintigraphy was positive in 45 of 57 patients (sensitivity, 79%) and in 113 of 154 disease sites (sensitivity, 69%), The sensitivity was higher in the more common types of LGNHL: follicular, predominantly small cleaved cell (FSC), and follicular, mixed small cleaved and Barge cell (FM) (84% and 91% in patients and 72% and 71% in disease sites, respectively), Sensitivity was lower in patients with mucosa-associated lymphoid tissue lymphoma (MALT) and small lymphocytic lymphoma (SL). Among 28 patients with disease recurrence after CCR (14 with and 14 without baseline studies), Ga-67 scan was positive in 25, for a sensitivity of 89% for detection of disease recurrence. Conclusion: When modern technology is used, Ga-67 scintigraphy has good sensitivity in patients with LGNHL. It therefore can be used to monitor response to therapy and to provide early detection of disease recurrence in these patients. (C) 1996 by American Society of Clinical Oncology.