Recent advances in the transmembrane transport of anions

被引:318
作者
Davis, Jeffery T. [1 ]
Okunola, Oluyomi [1 ]
Quesada, Roberto [2 ]
机构
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[2] Univ Burgos, Dept Quim, Burgos 09001, Spain
基金
美国国家科学基金会;
关键词
FACILITATED PHOSPHOLIPID TRANSLOCATION; ION-CHANNEL FORMATION; CHLORIDE TRANSPORT; PI SLIDES; FLIP-FLOP; FLUORESCENCE MEASUREMENT; CONFORMATIONAL CONTROL; MEMBRANE TRANSPORTERS; LIPID-BILAYERS; MECHANISM;
D O I
10.1039/b926164h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Anions cannot diffuse passively through biological membranes and membrane-bound proteins mainly govern the transmembrane movement of these charged species. The use of synthetic compounds that are able to facilitate the transmembrane transport of anions is a fascinating and burgeoning topic. The study of facilitated anion transport across lipid bilayers is an emerging field in supramolecular and bioorganic chemistry. In this critical review we describe the recent research progress in this area, focusing on literature published during the years 2007-2009. An overview of the assays that are used in the transmembrane transport of anions is also included (158 references).
引用
收藏
页码:3843 / 3862
页数:20
相关论文
共 158 条
[1]   Direct visualization of membrane leakage induced by the antibiotic peptides: Maculatin, citropin, and aurein [J].
Ambroggio, EE ;
Separovic, F ;
Bowie, JH ;
Fidelio, GD ;
Bagatolli, LA .
BIOPHYSICAL JOURNAL, 2005, 89 (03) :1874-1881
[2]  
ASHCROFT FM, 2001, ION CHANNELS DIS CHA, P481
[3]  
Ashley R.H., 1995, Ion Channels: A Practical Approach
[4]   An introduction to anion receptors based on organic frameworks [J].
Bates, Gareth W. ;
Gale, Philip A. .
RECOGNITION OF ANIONS, 2008, 129 :1-44
[5]   Ionic liquid-calix[4]pyrrole complexes: pyridinium inclusion in the calixpyrrole cup [J].
Bates, Gareth W. ;
Gale, Philip A. ;
Light, Mark E. .
CRYSTENGCOMM, 2006, 8 (04) :300-302
[6]   Catechols as Membrane Anion Transporters [J].
Berezin, Sofya Kostina ;
Davis, Jeffery T. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (07) :2458-+
[7]  
Bianchi A, 1997, SUPRAMOLECULAR CHEMISTRY OF ANIONS, P217
[8]   Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3 [J].
Bok, D ;
Galbraith, G ;
Lopez, I ;
Woodruff, M ;
Nusinowitz, S ;
BeltrandelRio, H ;
Huang, WH ;
Zhao, SL ;
Geske, R ;
Montgomery, C ;
Van Sligtenhorst, I ;
Friddle, C ;
Platt, K ;
Sparks, MJ ;
Pushkin, A ;
Abuladze, N ;
Ishiyama, A ;
Dukkipati, R ;
Liu, WX ;
Kurtz, I .
NATURE GENETICS, 2003, 34 (03) :313-319
[9]   Facilitated phospholipid translocation across vesicle membranes using low-molecular-weight synthetic flippases [J].
Boon, JM ;
Smith, BD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (50) :11924-11925
[10]   Facilitated phosphatidylserine (PS) flip-flop and thrombin activation using a synthetic PS scramblase [J].
Boon, JM ;
Lambert, TN ;
Sisson, AL ;
Davis, AP ;
Smith, BD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (27) :8195-8201