Catechols as Membrane Anion Transporters

被引：65

作者：

Berezin, Sofya Kostina ^{[1
]}

Davis, Jeffery T. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 07期

关键词：

TRANSMEMBRANE CONDUCTANCE REGULATOR; CONFORMATIONAL CONTROL; CHLORIDE TRANSPORT; ION CHANNELS; NMR; EXTRACTION; BINDING;

D O I：

10.1021/ja809733c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that are easier to dehydrate are made more permeable to the membrane by 3.

引用

页码：2458 / +

页数：3

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