Sensitivity and specificity of the borreliacidal-antibody test during early lyme disease: A ''gold standard''?

被引:41
作者
Callister, SM
Jobe, DA
Schell, RF
Pavia, CS
Lovrich, SD
机构
[1] UNIV WISCONSIN, WISCONSIN STATE LAB HYG, MADISON, WI 53706 USA
[2] UNIV WISCONSIN, DEPT MED MICROBIOL & IMMUNOL, MADISON, WI 53706 USA
[3] UNIV WISCONSIN, DEPT BACTERIOL, MADISON, WI 53706 USA
[4] NYCOM IMMUNODIAGNOST LAB, OLD WESTBURY, NY USA
[5] NEW YORK MED COLL, DEPT MED, VALHALLA, NY 10595 USA
关键词
D O I
10.1128/CDLI.3.4.399-402.1996
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The serodiagnosis of early Lyme disease has been plagued with problems of sensitivity and specificity. We found that the flow-cytometric borreliacidal-antibody test had a sensitivity of 72% for the detection of patients with early Lyme disease. By contrast, the sensitivity of the enzyme immunofluorescence assay was 28%, The enhanced sensitivity of the borreliacidal-antibody test was due to the use of Borrelia burgdorferi 50772, which lacks OspA and OspB. When B. burgdorferi 297, which expresses both OspA and OspB, was used, the sensitivity of the borreliacidal-antibody test was 15%. Our results also showed that the borreliacidal-antibody test was specific. No borreliacidal activity was detected in normal sera or in sera from patients with mononucleosis, rheumatoid factor, or syphilis. These results demonstrate that the flow-cytometric borreliacidal-antibody test may be the laboratory ''gold standard'' for the serodiagnosis of Lyme disease.
引用
收藏
页码:399 / 402
页数:4
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