Silence from within: Endogenous siRNAs and miRNAs

被引：212

作者：

Sontheimer, EJ ^{[1
]}

Carthew, RW ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

CELL | 2005年 / 122卷 / 01期

关键词：

D O I：

10.1016/j.cell.2005.06.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

引用

页码：9 / 12

页数：4

共 20 条

[1] MicroRNAs and other tiny endogenous RNAs in C-elegans [J].

Ambros, V ;

Lee, RC ;

Lavanway, A ;

Williams, PT ;

Jewell, D .

CURRENT BIOLOGY, 2003, 13 (10) :807-818

[2] The small RNA profile during Drosophila melanogaster development [J].

Aravin, AA ;

Lagos-Quintana, M ;

Yalcin, A ;

Zavolan, M ;

Marks, D ;

Snyder, B ;

Gaasterland, T ;

Meyer, J ;

Tuschl, T .

DEVELOPMENTAL CELL, 2003, 5 (02) :337-350

[3] Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line [J].

Aravin, AA ;

Klenov, MS ;

Vagin, VV ;

Bantignies, F ;

Cavalli, G ;

Gvozdev, VA .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (15) :6742-6750

[4] MicroRNA binding sites in Arabidopsis class IIIHD-ZIP mRNAs are required for methylation of the template chromosome [J].

Bao, N ;

Lye, KW ;

Barton, MK .

DEVELOPMENTAL CELL, 2004, 7 (05) :653-662

[5] Phylogenetic shadowing and computational identification of human microRNA genes [J].

Berezikov, E ;

Guryev, V ;

van de Belt, J ;

Wienholds, E ;

Plasterk, RHA ;

Cuppen, E .

CELL, 2005, 120 (01) :21-24

[6] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[7] AU binding proteins recruit the exosome to degrade ARE-containing mRNAs [J].

Chen, CY ;

Gherzi, R ;

Ong, SE ;

Chan, EKL ;

Raijmakers, R ;

Pruijn, GJM ;

Stoecklin, G ;

Moroni, C ;

Mann, M ;

Karin, M .

CELL, 2001, 107 (04) :451-464

[8] Unlocking the potential of the human genome with RNA interference [J].

Hannon, GJ ;

Rossi, JJ .

NATURE, 2004, 431 (7006) :371-378

[9] Involvement of MicroRNA in AU-rich element-mediated mRNA instability [J].

Jing, Q ;

Huang, S ;

Guth, S ;

Zarubin, T ;

Motoyama, A ;

Chen, JM ;

Di Padova, F ;

Lin, SC ;

Gram, H ;

Han, JH .

CELL, 2005, 120 (05) :623-634

[10] Human MicroRNA targets [J].

John, B ;

Enright, AJ ;

Aravin, A ;

Tuschl, T ;

Sander, C ;

Marks, DS .

PLOS BIOLOGY, 2004, 2 (11) :1862-1879

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