Silence from within: Endogenous siRNAs and miRNAs

被引：212

作者：

Sontheimer, EJ ^{[1
]}

Carthew, RW ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

CELL | 2005年 / 122卷 / 01期

关键词：

D O I：

10.1016/j.cell.2005.06.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.

引用

页码：9 / 12

页数：4

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