Effect of nano- and micro-hydroxyapatite/chitosan-gelatin network film on human gastric cancer cells

被引：56

作者：

Li, Junjie ^{[1
,2
]}

Yin, Yuji ^{[1
]}

Yao, Fanglian ^{[1
,2
]}

Zhang, Lili ^{[1
]}

Yao, Kangde ^{[1
]}

机构：

[1] Tianjin Univ, Res Inst Polymer Mat, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

来源：

MATERIALS LETTERS | 2008年 / 62卷 / 17-18期

关键词：

nano-hydroxyapatite; micro-hydroxyapatite; chitosan; gelation; anticancer;

D O I：

10.1016/j.matlet.2008.02.072

中图分类号：

T [工业技术];

学科分类号：

08 [工学];

摘要：

After a tumorotomy operation, desirable biomaterials should be able to inhibit the cancer cell growth around the defects. In this article, a comparative study of human gastric cancer SGC-7901 cells behavior on the microhydorxyapatite (mHA) and nano-hydroxyapatite (nHA) surface layer was carried out. nHA crystalline was biomineralized on the chitosan-gelatin network films and the mean size of the nHA crystalline was 17-25 nm evaluated by X-ray diffraction (XRD) and transmission electron microscope (TEM), while the sintered mHA with average size 5 mu m was deposited on the films directly. The surface characteristic observed by scanning electron microscope (SEM). MTT assay of SGC-7901 cells cultured on nHA and mHA surface suggested that nHA crystalline can effectively inhibit the proliferation performance of SGC-7901 cells. The size of HA crystalline has important influence on the adhesion performance and morphology of SGC-7901 cells. (c) 2008 Published by Elsevier B.V.

引用

页码：3220 / 3223

页数：4

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