Rapid development of a DNA vaccine for Zika virus

被引：334

作者：

Dowd, Kimberly A. ^{[1
]}

Ko, Sung-Youl ^{[2
]}

Morabito, Kaitlyn M. ^{[2
]}

Yang, Eun Sung ^{[2
]}

Pelc, Rebecca S. ^{[1
]}

DeMaso, Christina R. ^{[1
]}

Castilho, Leda R. ^{[2
,3
]}

Abbink, Peter ^{[4
]}

Boyd, Michael ^{[4
]}

Nityanandam, Ramya ^{[4
]}

Gordon, David N. ^{[1
]}

Gallagher, John Robert ^{[5
]}

Chen, Xuejun ^{[2
]}

Todd, John-Paul ^{[2
]}

Tsybovsky, Yaroslav ^{[6
]}

Harris, Audray ^{[5
]}

Huang, Yan-Jang S. ^{[7
]}

Higgs, Stephen ^{[7
]}

Vanlandingham, Dana L. ^{[7
]}

Andersen, Hanne ^{[8
]}

Lewis, Mark G. ^{[8
]}

De La Barrera, Rafael ^{[9
]}

Eckels, Kenneth H. ^{[9
]}

Jarman, Richard G. ^{[10
]}

Nason, Martha C. ^{[11
]}

Barouch, Dan H. ^{[4
]}

Roederer, Mario ^{[2
]}

Kong, Wing-Pui ^{[2
]}

Mascola, John R. ^{[2
]}

Pierson, Theodore C. ^{[1
]}

Graham, Barney S. ^{[2
]}

机构：

[1] NIAID, Viral Pathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] Univ Fed Rio de Janeiro, COPPE, Chem Engn Program, Inst Alberto Luiz Coimbra Posgrad & Pesquisa Engn, Rio De Janeiro, Brazil

[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[5] NIAID, Struct Informat Unit, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[6] Frederick Natl Lab Canc Res, Electron Microscopy Lab, Canc Res Technol Program, Frederick, MD 21702 USA

[7] Kansas State Univ, Coll Vet Med, Dept Diagnost Med Pathobiol, Manhattan, KS 66506 USA

[8] Bioqual, Rockville, MD 20852 USA

[9] Walter Reed Army Inst Res, Translat Med Branch, Silver Spring, MD 20910 USA

[10] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA

[11] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20852 USA

来源：

SCIENCE | 2016年 / 354卷 / 6309期

关键词：

JAPANESE ENCEPHALITIS-VIRUS; TICK-BORNE ENCEPHALITIS; DENGUE VIRUS; CANDIDATE VACCINE; HEALTHY-ADULTS; ANTIBODY; NEUTRALIZATION; PREMEMBRANE; PROTECTION; CHALLENGE;

D O I：

10.1126/science.aai9137

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of childbearing age and their partners is imperative. We found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZIKV challenge correlated with serum neutralizing activity. These data not only indicate that DNA vaccination could be a successful approach to protect against ZIKV infection, but also suggest a protective threshold of vaccine induced neutralizing activity that prevents viremia after acute infection.

引用

页码：237 / 240

页数：5

共 24 条

[1] Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Abbink, Peter
Larocca, Rafael A.
De La Barrera, Rafael A.
Bricault, Christine A.
Moseley, Edward T.
Boyd, Michael
Kirilova, Marinela
Li, Zhenfeng
Ng'ang'a, David
Nanayakkara, Ovini
Nityanandam, Ramya
Mercado, Noe B.
Borducchi, Erica N.
Agarwal, Arshi
Brinkman, Amanda L.
Cabral, Crystal
Chandrashekar, Abishek
Giglio, Patricia B.
Jetton, David
Jimenez, Jessica
Lee, Benjamin C.
Mojta, Shanell
Molloy, Katherine
Shetty, Mayuri
Neubauer, George H.
Stephenson, Kathryn E.
Peron, Jean Pierre S.
Zanotto, Paolo M. de A.
Misamore, Johnathan
Finneyfrock, Brad
Lewis, Mark G.
Alter, Galit
Modjarrad, Kayvon
Jarman, Richard G.
Eckels, Kenneth H.
Michael, Nelson L.
Thomas, Stephen J.
Barouch, Dan H.
[J]. SCIENCE, 2016, 353 (6304) : 1129 - 1132
[2] SYNTHESIS AND SECRETION OF RECOMBINANT TICK-BORNE ENCEPHALITIS-VIRUS PROTEIN-E IN SOLUBLE AND PARTICULATE FORM
ALLISON, SL
STADLER, K
MANDL, CW
KUNZ, C
HEINZ, FX
[J]. JOURNAL OF VIROLOGY, 1995, 69 (09) : 5816 - 5820
[3] Virus-like particles displaying envelope domain III of dengue virus type 2 induce virus-specific antibody response in mice
Arora, Upasana
Tyagi, Poornima
Swaminathan, Sathyamangalam
Khanna, Navin
[J]. VACCINE, 2013, 31 (06) : 873 - 878
[4] Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine
Catanzaro, Andrew T.
Roederer, Mario
Koup, Richard A.
Bailer, Robert T.
Enama, Mary E.
Nason, Martha C.
Martin, Julie E.
Rucker, Steve
Andrews, Charla A.
Gomez, Phillip L.
Mascola, John R.
Nabel, Gary J.
Graham, Barney S.
[J]. VACCINE, 2007, 25 (20) : 4085 - 4092
[5] Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and Japanese encephalitis virus
Chang, GJJ
Hunt, AR
Holmes, DA
Springfield, T
Chiueh, TS
Roehrig, JT
Gubler, DJ
[J]. VIROLOGY, 2003, 306 (01) : 170 - 180
[6] Chang GJJ, 2001, ANN NY ACAD SCI, V951, P272
[7] West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays
Davis, BS
Chang, GJJ
Cropp, B
Roehrig, JT
Martin, DA
Mitchell, CJ
Bowen, R
Bunning, ML
[J]. JOURNAL OF VIROLOGY, 2001, 75 (09) : 4040 - 4047
[8] A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
Dejnirattisai, Wanwisa
Wongwiwat, Wiyada
Supasa, Sunpetchuda
Zhang, Xiaokang
Dai, Xinghong
Rouvinsky, Alexander
Jumnainsong, Amonrat
Edwards, Carolyn
Nguyen Than Ha Quyen
Duangchinda, Thaneeya
Grimes, Jonathan M.
Tsai, Wen-Yang
Lai, Chih-Yun
Wang, Wei-Kung
Malasit, Prida
Farrar, Jeremy
Simmons, Cameron P.
Zhou, Z. Hong
Rey, Felix A.
Mongkolsapaya, Juthathip
Screaton, Gavin R.
[J]. NATURE IMMUNOLOGY, 2015, 16 (02) : 170 - +
[9] Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype
Dowd, Kimberly A.
DeMaso, Christina R.
Pelc, Rebecca S.
Speer, Scott D.
Smith, Alexander R. Y.
Goo, Leslie
Platt, Derek J.
Mascola, John R.
Graham, Barney S.
Mulligan, Mark J.
Diamond, Michael S.
Ledgerwood, Julie E.
Pierson, Theodore C.
[J]. CELL REPORTS, 2016, 16 (06): : 1485 - 1491
[10] Molecular organization of a recombinant subviral particle from tick-borne encephalitis
Ferlenghi, I
Clarke, M
Ruttan, T
Allison, SL
Schalich, J
Heinz, FX
Harrison, SC
Rey, FA
Fuller, SD
[J]. MOLECULAR CELL, 2001, 7 (03) : 593 - 602

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