IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes

被引：33

作者：

Barker, Brianne R.

Parvani, Jenny G.

Meyer, Debra

Hey, Adam S.

Skak, Kresten

Letvin, Norman L.

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Viral Pathogenesis,Dept Med, Boston, MA 02215 USA

[2] Univ Johannesburg, Dept Biochem, Auckland, New Zealand

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 179卷 / 06期

关键词：

COMMON GAMMA-CHAIN; ANNEXIN-V BINDS; B-CELLS; IMMUNODEFICIENCY DISEASES; SELECTIVE EXPRESSION; IMMUNE-RESPONSES; NK CELLS; RECEPTOR; ACTIVATION; INTERLEUKIN-21;

D O I：

10.4049/jimmunol.179.6.3596

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-21, a member of the common gamma-chain family of cytokines, has pleiotropic effects on T, B, and NK cells. We found that IL-21 and the prototype common gamma-chain cytokine IL-2 can stimulate proliferation and cytokine secretion by Ag-specific rhesus monkey CD8(+) T cells. However, unique among the members of this family of cytokines, we found that IL-21 drives these cells to apoptosis by down-regulation of Bcl-2. These findings suggest that IL-21 may play an important role in the contraction of CD8(+) T cell responses.

引用

页码：3596 / 3603

页数：8

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