Expression of monocyte chemoattractant protein-1 mRNA and protein in cultured human thyrocytes

被引：42

作者：

Kasai, K ^{[1
]}

Banba, N ^{[1
]}

Motohashi, S ^{[1
]}

Hattori, Y ^{[1
]}

Manaka, K ^{[1
]}

Shimoda, SI ^{[1
]}

机构：

[1] DOKKYO UNIV, SCH MED, CTR TISSUE CULTURE, MIBU, TOCHIGI 32102, JAPAN

来源：

FEBS LETTERS | 1996年 / 394卷 / 02期

关键词：

thyrocyte; monocyte chemoattractant protein-1; interleukin-1; tumor necrosis factor-alpha; interferon-gamma;

D O I：

10.1016/0014-5793(96)00935-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocytes as well as lymphocytes infiltrate in the stroma of thyroid tissue in autoimmune and destructive thyroiditis, Monocyte chemoattractant protein-1 (MCP-1) is a cytokine that attracts T-lymphocytes as well as monocytes, Using human thyrocytes in primary cultures, we show that expression of MCP-1 mRNA and protein is remarkably stimulated by both interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), and also that interferon-gamma (IFN-gamma) by itself is a weak stimulant but has a synergistic activity with either IL-1 or TNF-alpha. The finding indicates that MCP-1 can be produced by thyrocytes themselves, suggesting a possible role of thyrocytes on accumulation of monocytes and T-lymphocytes to the tissue from the blood in autoimmune and destructive thyroiditis.

引用

页码：137 / 140

页数：4

共 35 条

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