Expression of monocyte chemoattractant protein-1 mRNA and protein in cultured human thyrocytes

被引：42

作者：

Kasai, K ^{[1
]}

Banba, N ^{[1
]}

Motohashi, S ^{[1
]}

Hattori, Y ^{[1
]}

Manaka, K ^{[1
]}

Shimoda, SI ^{[1
]}

机构：

[1] DOKKYO UNIV, SCH MED, CTR TISSUE CULTURE, MIBU, TOCHIGI 32102, JAPAN

来源：

FEBS LETTERS | 1996年 / 394卷 / 02期

关键词：

thyrocyte; monocyte chemoattractant protein-1; interleukin-1; tumor necrosis factor-alpha; interferon-gamma;

D O I：

10.1016/0014-5793(96)00935-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocytes as well as lymphocytes infiltrate in the stroma of thyroid tissue in autoimmune and destructive thyroiditis, Monocyte chemoattractant protein-1 (MCP-1) is a cytokine that attracts T-lymphocytes as well as monocytes, Using human thyrocytes in primary cultures, we show that expression of MCP-1 mRNA and protein is remarkably stimulated by both interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), and also that interferon-gamma (IFN-gamma) by itself is a weak stimulant but has a synergistic activity with either IL-1 or TNF-alpha. The finding indicates that MCP-1 can be produced by thyrocytes themselves, suggesting a possible role of thyrocytes on accumulation of monocytes and T-lymphocytes to the tissue from the blood in autoimmune and destructive thyroiditis.

引用

页码：137 / 140

页数：4

共 35 条

[11] THE INTERLEUKIN-8-RECEPTOR FAMILY - FROM CHEMOKINES TO MALARIA
HORUK, R
[J]. IMMUNOLOGY TODAY, 1994, 15 (04): : 169 - 174
[12] ANTITUMOR PROMOTION AND ANTIINFLAMMATION - DOWN-MODULATION OF AP-1 (FOS JUN) ACTIVITY BY GLUCOCORTICOID HORMONE
JONAT, C
RAHMSDORF, HJ
PARK, KK
CATO, ACB
GEBEL, S
PONTA, H
HERRLICH, P
[J]. CELL, 1990, 62 (06) : 1189 - 1204
[13] JONES ML, 1992, LAB INVEST, V66, P498
[14] REGULATION OF INDUCIBLE NITRIC-OXIDE PRODUCTION BY CYTOKINES IN HUMAN THYROCYTES IN CULTURE
KASAI, K
HATTORI, Y
NAKANISHI, N
MANAKA, K
BANBA, N
MOTOHASHI, S
SHIMODA, SI
[J]. ENDOCRINOLOGY, 1995, 136 (10) : 4261 - 4270
[15] ENHANCED PRODUCTION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 IN RHEUMATOID-ARTHRITIS
KOCH, AE
KUNKEL, SL
HARLOW, LA
JOHNSON, B
EVANOFF, HL
HAINES, GK
BURDICK, MD
POPE, RM
STRIETER, RM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (03) : 772 - 779
[16] THE NEUTROPHIL-ACTIVATING PROTEIN (NAP-1) IS ALSO CHEMOTACTIC FOR LYMPHOCYTES-T
LARSEN, CG
ANDERSON, AO
APPELLA, E
OPPENHEIM, JJ
MATSUSHIMA, K
[J]. SCIENCE, 1989, 243 (4897) : 1464 - 1466
[17] MONOCYTE CHEMOTACTIC PROTEINS MCP-1, MCP-2, AND MCP-3 ARE MAJOR ATTRACTANTS FOR HUMAN CD4(+) AND CD8(+) T-LYMPHOCYTES
LOETSCHER, P
SEITZ, M
CLARKLEWIS, I
BAGGIOLINI, M
MOSER, B
[J]. FASEB JOURNAL, 1994, 8 (13) : 1055 - 1060
[18] CULTURED HUMAN LIVER FAT-STORING CELLS PRODUCE MONOCYTE CHEMOTACTIC PROTEIN-1 - REGULATION BY PROINFLAMMATORY CYTOKINES
MARRA, F
VALENTE, AJ
PINZANI, M
ABBOUD, HE
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) : 1674 - 1680
[19] MOLECULAR-CLONING OF A HUMAN MONOCYTE-DERIVED NEUTROPHIL CHEMOTACTIC FACTOR (MDNCF) AND THE INDUCTION OF MDNCF MESSENGER-RNA BY INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR
MATSUSHIMA, K
MORISHITA, K
YOSHIMURA, T
LAVU, S
KOBAYASHI, Y
LEW, W
APPELLA, E
KUNG, HF
LEONARD, EJ
OPPENHEIM, JJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (06) : 1883 - 1893
[20] MUKAIDA N, 1991, J IMMUNOL, V146, P1212

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