The role of IFN-γ in systemic lupus erythematosus:: a challenge to the Th1/Th2 paradigm in autoimmunity

被引:168
作者
Theofilopoulos, AN [1 ]
Koundouris, S [1 ]
Kono, DH [1 ]
Lawson, BR [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
关键词
cytokines; IFN-gamma; lupus; Th1; Th2;
D O I
10.1186/ar290
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The classification of T helper cells into type 1 (Th1) and type 2 (Th2) led to the hypothesis that Th1 cells and their cytokines (interleukin [IL]-2, interferon [IFN]-gamma) are involved in cell-mediated autoimmune diseases, and that Th2 cells and their cytokines (IL-4, IL-5, IL-10, IL-13) are involved in autoantibody( humoral)-mediated autoimmune diseases. However, this paradigm has been refuted by recent studies in several induced and spontaneous mouse models of systemic lupus erythematosus, which showed that IFN-gamma is a major effector molecule in this disease. These and additional findings, reviewed here, suggest that these two cross-talking classes of cytokines can exert autoimmune disease-promoting or disease-inhibiting effects without predictability or strict adherence to the Th1-versus-Th2 dualism.
引用
收藏
页码:136 / 141
页数:6
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