New pancreas from old: microregulators of pancreas regeneration

被引：91

作者：

Joglekar, Mugdha V. ^{[1
]}

Parekh, Vishal S. ^{[1
]}

Hardikar, Anandwardhan A. ^{[1
]}

机构：

[1] Natl Ctr Cell Sci, Stem Cells & Diabet Sect, Lab 10, Pune 411007, Maharashtra, India

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2007年 / 18卷 / 10期

关键词：

D O I：

10.1016/j.tem.2007.10.001

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

MicroRNAs (miRNAs) are 18-22 nucleotide RNA molecules that mediate post-transcriptional gene silencing, primarily by binding to the 3' untranslated region of their target mRNA. Several studies have demonstrated the role of miRNAs in mouse pancreas development (miR-124a, miR-503, miR-541, miR-214) as well as in insulin secretion (miR-375, miR-9). Pancreatic transcription factors that are temporally expressed during early pancreas development are re-expressed during pancreas regeneration following pancreatectomy in mice. The only exception to this is Neurogenin3 (NGN3). Here, we discuss recent evidence for miRNA-mediated silencing of ngn3, which inhibits endocrine cell development via the classical 'stem cell pathway' during mouse pancreatic regeneration, thereby favoring beta-cell regeneration.

引用

页码：393 / 400

页数：8

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