parD toxin-antitoxin system of plasmid R1-basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems

被引：25

作者：

Diago-Navarro, Elizabeth ^{[1
]}

Hernandez-Arriaga, Ana M. ^{[1
]}

Lopez-Villarejo, Juan ^{[1
]}

Munoz-Gomez, Ana J. ^{[1
]}

Kamphuis, Monique B. ^{[2
]}

Boelens, Rolf ^{[2
]}

Lemonnier, Marc ^{[3
]}

Diaz-Orejas, Ramon ^{[1
]}

机构：

[1] CSIC, Ctr Invest Biol, Madrid 28040, Spain

[2] Univ Utrecht, NMR Dept, Utrecht, Netherlands

[3] ANTABIO SAS, Incubateur Midi Pyrenees, Toulouse, France

来源：

FEBS JOURNAL | 2010年 / 277卷 / 15期

关键词：

bacterial RNases; gene regulation; Kid toxin and Kis antitoxin; parD operon; plasmid maintenance; plasmid R1; toxin-antitoxin systems; translation inhibition; PROGRAMMED CELL-DEATH; MESSENGER-RNA INTERFERASE; ESCHERICHIA-COLI; F-PLASMID; STABILITY SYSTEM; STABLE MAINTENANCE; CRYSTAL-STRUCTURE; BACTERIAL TOXIN; STRUCTURAL BASIS; DNA RECOGNITION;

D O I：

10.1111/j.1742-4658.2010.07722.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toxin-antitoxin systems, as found in bacterial plasmids and their host chromosomes, play a role in the maintenance of genetic information, as well as in the response to stress. We describe the basic biology of the parD/kiskid toxin-antitoxin system of Escherichia coli plasmid R1, with an emphasis on regulation, toxin activity, potential applications in biotechnology and its relationships with related toxin-antitoxin systems. Special reference is given to the ccd toxin-antitoxin system of plasmid F because its toxin shares structural homology with the toxin of the parD system. Inter-relations with related toxin-antitoxin systems present in the E. coli chromosome, such as the parD homologues chpA/mazEF and chpB and the relBE system, are also reviewed. The combined structural and functional information that is now available on all these systems, as well as the ongoing controversy regarding the role of the chromosomal toxin-antitoxin loci, have made this review especially timely.

引用

页码：3097 / 3117

页数：21

共 141 条

[21] Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids [J].