What an epigenome remembers

被引：45

作者：

Lange, Ulrike C. ^{[1
]}

Schneider, Robert ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol, D-79108 Freiburg, Germany

来源：

BIOESSAYS | 2010年 / 32卷 / 08期

关键词：

epigenetics; histone modification; transmission of marks; TRANSGENERATIONAL EPIGENETIC INHERITANCE; HISTONE ARGININE METHYLATION; DNA METHYLATION; MISSING HERITABILITY; GERMLINE EPIMUTATION; GENE-EXPRESSION; AGOUTI LOCUS; PRADER-WILLI; CELL LINEAGE; LYSINE;

D O I：

10.1002/bies.201000030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During mammalian development, maintenance of cell fate through mitotic divisions require faithful replication not only of the DNA but also of a particular epigenetic state. Germ line cells have the capacity of erasing this epigenetic memory at crucial times during development, thereby resetting their epigenome. Certain marks, however, appear to escape this reprogramming, which allows their transmission to the offspring and potentially guarantees transgenerational epigenetic inheritance. Here we discuss the molecular requirements for faithful transmission of epigenetic information and our current knowledge about the transmission of epigenetic information through generations.

引用

页码：659 / 668

页数：10

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