The human sperm epigenome and its potential role in embryonic development

被引：155

作者：

Carrell, Douglas T. ^{[1
]}

Hammoud, Saher Sue

机构：

[1] Univ Utah, Sch Med, Dept Urol Surg, IVF & Androl Labs, Salt Lake City, UT 84108 USA

来源：

MOLECULAR HUMAN REPRODUCTION | 2010年 / 16卷 / 01期

关键词：

methylation; histone; in vitro fertilization; embryogenesis; epigenetic; IN-VITRO FERTILIZATION; MALE GERM-CELLS; ASSISTED REPRODUCTIVE TECHNOLOGY; BECKWITH-WIEDEMANN-SYNDROME; INHIBITOR TRICHOSTATIN-A; DE-NOVO METHYLATION; DNA METHYLATION; GENOME-WIDE; HISTONE H3; MALE-INFERTILITY;

D O I：

10.1093/molehr/gap090

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Along with many of the genome-wide transitions in chromatin composition throughout spermatogenesis, epigenetic modifications on histone tails and DNA are continuously modified to ensure stage specific gene expression in the maturing spermatid. Recent findings have suggested that the repertoire of epigenetic modifications in the mature sperm may have a potential role in the developing embryo and alterations in the epigenetic profile have been associated with infertility. These changes include DNA demethylation and the retention of modified histones at important developmental, signaling and micro-RNA genes, which resemble the epigenetic state of an embryonic stem cell. This review assesses the significance of epigenetic changes during spermatogenesis, and provides insight on recent associations made between altered epigenetic profiles in the mature sperm and its relationship to infertility.

引用

页码：37 / 47

页数：11

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