The dinB operon and spontaneous mutation in Escherichia coli

被引：56

作者：

McKenzie, GJ

Magner, DB

Lee, PL

Rosenberg, SM

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Interdepartmental Grad Program Cell & Mol Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 13期

关键词：

D O I：

10.1128/JB.185.13.3972-3977.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Apparently conflicting data regarding the role of SOS-inducible, error-prone DNA polymerase IV (DinB) in spontaneous mutation are resolved by the finding that mutation is reduced by a polar allele with which dinB and neighboring yafN are deleted but not by two nonpolar dinB alleles. We demonstrate the existence of a dinB operon that contains four genes, dinB-yafN-yafO-yafP. The results imply a role for yafN, yafO, and/or yafP in spontaneous mutation.

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页码：3972 / 3977

页数：6

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