The impact of a negligent G2/M checkpoint on genomic instability and cancer induction

被引：460

作者：

Loebrich, Markus

Jeggo, Penny A.

机构：

[1] Tech Univ Darmstadt, D-64287 Darmstadt, Germany

[2] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrc2248

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA damage responses (DDR) encompass DNA repair and signal transduction pathways that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low levels of DNA damage, including low doses of ionizing radiation, is crucial for assessing environmental cancer risk. It has been assumed that damage-induced cell cycle checkpoints respond to a single double strand break (DSB) but the G2/M checkpoint, which prevents entry into mitosis, has recently been shown to have a defined threshold of 10-20 DSBs. Here, we consider the impact of a negligent G2/M checkpoint on genomic stability and cancer risk.

引用

页码：861 / 869

页数：9

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