Rod models of DNA: sequence-dependent anisotropic elastic modelling of local bending phenomena

被引：121

作者：

Munteanu, MG

Vlahovicek, K

Parthasarathy, S

Simon, I

Pongor, S

机构：

[1] Int Ctr Genet Engn & Biotechnol, I-34012 Trieste, Italy

[2] Hungarian Acad Sci, Inst Enzymol, BRC, H-1518 Budapest, Hungary

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 09期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S0968-0004(98)01265-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Local bending phenomena can be predicted by elastic models that incorporate sequence-dependent anisotropic-bendability (SDAB). SDAB models consider DNA to be an initially straight, segmented, elastic rod, in which the flexibility of each segment is greater towards the major groove than it is in other directions. While local bending can be predicted by static-geometry models as well, SDAB models, in addition, qualitatively explain such phenomena as the affinity of protein binding and kinking. A set of prediction tools is available at http://www.icgeb.trieste.it/dna.

引用

页码：341 / 347

页数：7

共 40 条

[1]

[Anonymous], DNA TOPOLOGY ITS BIO

[2]

BANSAL M, 1995, COMPUT APPL BIOSCI, V11, P281

[3] THEORY OF TWISTING AND BENDING OF CHAIN MACROMOLECULES - ANALYSIS OF THE FLUORESCENCE DEPOLARIZATION OF DNA [J].