miR-126 functions as a tumour suppressor in human gastric cancer

被引：296

作者：

Feng, Runhua ^{[1
,2
,3
]}

Chen, Xuehua ^{[1
,3
]}

Yu, Yingyan ^{[1
,3
]}

Su, Liping ^{[1
,3
]}

Yu, Beiqin ^{[1
,3
]}

Li, Jianfang ^{[1
,3
]}

Cai, Qu ^{[1
,3
]}

Yan, Min ^{[1
,2
,3
]}

Liu, Bingya ^{[1
,3
]}

Zhu, Zhenggang ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Gastr Neoplasms, Ruijin Hosp, Shanghai 20025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Dept Surg, Ruijin Hosp, Shanghai 20025, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Digest Surg, Ruijin Hosp, Shanghai 20025, Peoples R China

来源：

CANCER LETTERS | 2010年 / 298卷 / 01期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

MicroRNA; Gastric cancer; Proliferation; Invasion; Crk; ADAPTER PROTEIN CRK; HUMAN OVARIAN-CANCER; DOWN-REGULATION; MALIGNANT FEATURE; BREAST-CANCER; EXPRESSION; MICRORNA; INVASION; METASTASIS; INVOLVEMENT;

D O I：

10.1016/j.canlet.2010.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs have emerged as important gene regulators and are recognised as key players in carcinogenesis. In the present study, we show that miR-126 was significantly down-regulated in gastric cancer tissues compared with matched normal tissues and was associated with clinicopathological features, including tumour size, lymph node metastasis, local invasion and tumour-node-metastasis (TNM) stage. Ectopic expression of miR-126 in SGC-7901 gastric cancer cells potently inhibited cell growth by inducing cell cycle arrest in G0/G1 phase, migration and invasion in vitro as well as tumorigenicity and metastasis in vivo. Mechanistically, we identified the adaptor protein Crk as a target of miR-126. Taken together, our results suggest that miR-126 may function as a tumour suppressor in gastric cancer, with Crk as a direct target. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：50 / 63

页数：14

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