Efficacy of treatment for unexplained infertility

被引：187

作者：

Guzick, DS

Sullivan, MW

Adamson, GD

Cedars, MI

Falk, RJ

Peterson, EP

Steinkampf, MP

机构：

[1] Univ Rochester, Dept Obstet & Gynecol, Rochester, NY 14642 USA

[2] Fertil Phys No Calif, Palo Alto, CA USA

[3] SUNY Buffalo, Buffalo, NY 14260 USA

[4] Univ Cincinnati, Cincinnati, OH USA

[5] Columbia Hosp Women, Washington, DC USA

[6] Ann Arbor Reprod Associates, Ypsilanti, MI USA

[7] Univ Alabama Birmingham, Birmingham, AL USA

来源：

FERTILITY AND STERILITY | 1998年 / 70卷 / 02期

关键词：

unexplained infertility; cost-effectiveness; clomiphene citrate; human menopausal gonadotropins; assisted reproduction; intrauterine insemination;

D O I：

10.1016/S0015-0282(98)00177-0

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To analyze the efficacy and cost-effectiveness of alternative treatments for unexplained infertility. Design: Retrospective analysis of 45 published reports. Setting: Clinical practices. Patient(s): Couples who met criteria for unexplained infertility. Women with Stage I or Stage II endometriosis were included. Intervention(s): Observation; clomiphene citrate (CC); gonadotropins (hMG); IUI; and GIFT and IVF. Main Outcome Measure(s): Clinical pregnancy rate. Result(s): Combined pregnancy rates per initiated cycle, adjusted for study quality, were as follows: no treatment = 1.3%-4.1%; IUI = 3.8%; CC = 5.6%; CC + IUI = 8.3%; hMG = 7.7%; hMG + IUI = 17.1%; IVF = 20.7%; GIFT = 27.0%. The estimated cost per pregnancy was $10,000 for CC + IUI, $17,000 for hMG + IUI, and $50,000 for IVF. Conclusion(s): Clomiphene citrate + IUI is a cost-effective treatment for unexplained infertility. If this treatment fails, hMG + IUI and assisted reproduction are efficacious therapeutic options. (Fertil Steril(R) 1998;70:207-13. (C)1998 by American Society for Reproductive Medicine.).

引用

页码：207 / 213

页数：7

共 62 条

[61] 80 CONSECUTIVE CASES OF GAMETE INTRA-FALLOPIAN TRANSFER [J].