Myelination and support of axonal integrity by glia

被引：766

作者：

Nave, Klaus-Armin ^{[1
]}

机构：

[1] Max Planck Inst Expt Med, Dept Neurogenet, D-37075 Gottingen, Germany

来源：

NATURE | 2010年 / 468卷 / 7321期

关键词：

PELIZAEUS-MERZBACHER-DISEASE; PROTEOLIPID PROTEIN GENE; CENTRAL-NERVOUS-SYSTEM; OLIGODENDROCYTE PRECURSOR CELLS; VANISHING WHITE-MATTER; SCHWANN-CELLS; MULTIPLE-SCLEROSIS; MOUSE MODEL; ACTION-POTENTIALS; TRANSGENIC MICE;

D O I：

10.1038/nature09614

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain. Cell biology and mouse genetics have provided insight into axon-glia signalling and the molecular architecture of the myelin sheath. Glial cells that myelinate axons were found to have a dual role by also supporting the long-term integrity of those axons. This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders.

引用

页码：244 / 252

页数：9

共 101 条

[1]

Anderson TJ, 1998, J COMP NEUROL, V394, P506, DOI 10.1002/(SICI)1096-9861(19980518)394:4<506::AID-CNE8>3.0.CO

[2]

2-5

[3] Peroxisomes, Myelination, and Axonal Integrity in the CNS [J].

Baes, Myriam ;

Aubourg, Patrick .

NEUROSCIENTIST, 2009, 15 (04) :367-379

[4] PROLIFERATION OF OLIGODENDROCYTE PRECURSOR CELLS DEPENDS ON ELECTRICAL-ACTIVITY IN AXONS [J].

BARRES, BA ;

RAFF, MC .

NATURE, 1993, 361 (6409) :258-260

[5] Extensive piano practicing has regionally specific effects on white matter development [J].

Bengtsson, SL ;

Nagy, Z ;

Skare, S ;

Forsman, L ;

Forssberg, H ;

Ullén, F .

NATURE NEUROSCIENCE, 2005, 8 (09) :1148-1150

[6] Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus [J].

Bergles, DE ;

Roberts, JDB ;

Somogyi, P ;

Jahr, CE .

NATURE, 2000, 405 (6783) :187-191

[7] Neuron-glia synapses in the brain [J].

Bergles, Dwight E. ;

Jabs, Ronald ;

Steinhaeuser, Christian .

BRAIN RESEARCH REVIEWS, 2010, 63 (1-2) :130-137

[8] Formation of compact myelin is required for maturation of the axonal cytoskeleton [J].

Brady, ST ;

Witt, AS ;

Kirkpatrick, LL ;

de Waegh, SM ;

Readhead, C ;

Tu, PH ;

Lee, VMY .

JOURNAL OF NEUROSCIENCE, 1999, 19 (17) :7278-7288

[9] Axonal prion protein is required for peripheral myelin maintenance [J].

Bremer, Juliane ;

Baumann, Frank ;

Tiberi, Cinzia ;

Wessig, Carsten ;

Fischer, Heike ;

Schwarz, Petra ;

Steele, Andrew D. ;

Toyka, Klaus V. ;

Nave, Klaus-Armin ;

Weis, Joachim ;

Aguzzi, Adriano .

NATURE NEUROSCIENCE, 2010, 13 (03) :310-U9

[10] Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system [J].

Brinkmann, Bastian G. ;

Agarwal, Amit ;

Sereda, Michael W. ;

Garratt, Alistair N. ;

Mueller, Thomas ;

Wende, Hagen ;

Stassart, Ruth M. ;

Nawaz, Schanila ;

Humml, Christian ;

Velanac, Viktorija ;

Radyushkin, Konstantin ;

Goebbels, Sandra ;

Fischer, Tobias M. ;

Franklin, Robin J. ;

Lai, Cary ;

Ehrenreich, Hannelore ;

Birchmeier, Carmen ;

Schwab, Markus H. ;

Nave, Klaus Armin .

NEURON, 2008, 59 (04) :581-595

← 1 2 3 4 5 6 7 8 9 10 →