Myelination and support of axonal integrity by glia

被引：766

作者：

Nave, Klaus-Armin ^{[1
]}

机构：

[1] Max Planck Inst Expt Med, Dept Neurogenet, D-37075 Gottingen, Germany

来源：

NATURE | 2010年 / 468卷 / 7321期

关键词：

PELIZAEUS-MERZBACHER-DISEASE; PROTEOLIPID PROTEIN GENE; CENTRAL-NERVOUS-SYSTEM; OLIGODENDROCYTE PRECURSOR CELLS; VANISHING WHITE-MATTER; SCHWANN-CELLS; MULTIPLE-SCLEROSIS; MOUSE MODEL; ACTION-POTENTIALS; TRANSGENIC MICE;

D O I：

10.1038/nature09614

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain. Cell biology and mouse genetics have provided insight into axon-glia signalling and the molecular architecture of the myelin sheath. Glial cells that myelinate axons were found to have a dual role by also supporting the long-term integrity of those axons. This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders.

引用

页码：244 / 252

页数：9

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