The interaction of tributyllead with lysosomes from rat liver

被引：7

作者：

Bragadin, M

Marton, D

Manente, S

Toninello, A

机构：

[1] Univ Venice, Dipartimento Sci Ambientali, I-30123 Venice, Italy

[2] Univ Padua, Dipartimento Chim Inorgan Met & Analit, I-35131 Padua, Italy

[3] Univ Padua, Dipartimento Chim Biol, I-35121 Padua, Italy

[4] CNR, Ctr Studio Biomembrane, I-35121 Padua, Italy

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2001年 / 83卷 / 2-3期

关键词：

lysosomes; tributyllead; uncoupling;

D O I：

10.1016/S0162-0134(00)00195-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions of tributyllead with lysosomes from rat liver have been studied. It results that the organometal compound induces a fast alkalinization in energized lysosomes. The interpretation is that the compound is a potent proton carrier. This function could explain the toxicity, in particular at neurological level of the compound. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：229 / 232

页数：4

共 27 条

[11] EVIDENCE FOR AN ATP-DRIVEN PROTON PUMP IN RAT-LIVER LYSOSOMES BY BASIC-DYES UPTAKE [J].