Coping with DNA double strand breaks

被引：92

作者：

Hiom, Kevin ^{[1
,2
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Biomed Res Inst, Dundee DD1 9SY, Scotland

[2] Univ Dundee, Ninewells Hosp & Med Sch, Dundee Canc Ctr, Dundee DD1 9SY, Scotland

来源：

DNA REPAIR | 2010年 / 9卷 / 12期

关键词：

DNA repair; DNA double strand breaks; Non-homologous end-joining; Homologous recombination; DEPENDENT PROTEIN-KINASE; HOLLIDAY JUNCTION RESOLVASE; CLASS-SWITCH RECOMBINATION; XRCC4-DNA LIGASE-IV; V(D)J RECOMBINATION; HOMOLOGOUS RECOMBINATION; CELL-CYCLE; FANCONI-ANEMIA; END RESECTION; KU PROTEIN;

D O I：

10.1016/j.dnarep.2010.09.018

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.

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收藏

页码：1256 / 1263

页数：8

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