Determination of essential amino acids involved in the CD4-independent tropism of the X4 human immunodeficiency virus type 1 m7NDK isolate: Role of potential N glycosylations in the C2 and V3 regions of gp120

被引：27

作者：

Dumonceaux, J

Goujon, C

Joliot, V

Briand, P

Hazan, U

机构：

[1] Inst Cochin Genet Mol, Lab Pathol & Genet Expt, INSERM, U380, F-75014 Paris, France

[2] Univ Paris 07, UFR Biochim, F-75005 Paris, France

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 11期

关键词：

D O I：

10.1128/JVI.75.11.5425-5428.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Seven mutations in the C2, V3, and C3 regions of gp120 are implicated in the tropism of the first CD4-independent human immunodeficiency virus type 1 isolate, m7NDK. Site-directed mutagenesis revealed that three amino acids are essential to maintain this tropism, one in the C2 region and two in the V3 loop. Two mutations implied N glycosylation modifications.

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页码：5425 / 5428

页数：4

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