Excitotoxic effect of kainic acid on chicken cochlear afferent neurons

被引：10

作者：

Shero, M ^{[1
]}

Salvi, RJ ^{[1
]}

Chen, L ^{[1
]}

Hashino, E ^{[1
]}

机构：

[1] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA

来源：

NEUROSCIENCE LETTERS | 1998年 / 257卷 / 02期

关键词：

kainic acid; excitotoxicity; glutamate; cochlea; afferent neuron; chicken;

D O I：

10.1016/S0304-3940(98)00821-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The excitotoxic effects of kainic acid, a glutamate analog, on the auditory neurons in the chicken cochlea were assessed by light and transmission electron microscopy. Kainic acid was directly applied onto the round window of adult chickens and their cochleas were harvested 3 h after application. Transverse microscopic sections of the basilar papilla revealed swelling of afferent dendrites without any morphological changes in efferent endings. The regions of the basilar papilla damaged by kainic acid were localized in the apical 80% and primarily on the neural side where tall hair cells are located. The basal, abneural short hair cell region was devoid of damage. These results imply that glutamate is a primary neurotransmitter in chicken auditory afferent neurons that synapse on tall hair cells. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：81 / 84

页数：4

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