Epigenetics of haematopoietic cell development

被引：131

作者：

Cedar, Howard ^{[1
]}

Bergman, Yehudit ^{[1
]}

机构：

[1] Hebrew Univ Med Sch, Dept Dev Biol & Canc Res, Inst Med Res Israel Canada, IL-91120 Jerusalem, Israel

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 07期

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; HEAVY-CHAIN GENE; COMMON LYMPHOID PROGENITORS; TISSUE-SPECIFIC ENHANCERS; ACTIVE DNA DEMETHYLATION; IG-KAPPA LOCUS; B-CELL; V(D)J RECOMBINATION; ALLELIC EXCLUSION; TRANSCRIPTION FACTORS;

D O I：

10.1038/nri2991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cells of the immune system are generated through a developmental cascade that begins in haematopoietic stem cells. During this process, gene expression patterns are programmed in a series of stages that bring about the restriction of cell potential, ultimately leading to the formation of specialized innate immune cells and mature lymphocytes that express antigen receptors. These events involve the regulation of both gene expression and DNA recombination, mainly through the control of chromatin accessibility. In this Review, we describe the epigenetic changes that mediate this complex differentiation process and try to understand the logic of the programming mechanism.

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收藏

页码：478 / 488

页数：11

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