Role of Toll-like receptors in inflammatory response in macrophages

被引：79

作者：

Aderem, A ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

CRITICAL CARE MEDICINE | 2001年 / 29卷 / 07期

关键词：

Toll-like receptors; bacterial lipopolysaccharide; endotoxin; innate immunity; macrophages; inflammation; signal transduction; cytokines; pattern-recognition receptors; pathogen-associated molecular patterns;

D O I：

10.1097/00003246-200107001-00008

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The innate immune response is the first line of defense against infectious disease. It is vital that the host detect the pathogen and rapidly mount a defense. The Toll-like family of receptors have evolved to detect conserved patterns on pathogens. When stimulated, these receptors activate the inflammatory response.

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收藏

页码：S16 / S18

页数：3

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