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The role of phosphoinositides in membrane transport

被引：390
作者：
Simonsen, A
Wurmser, AE
Emr, SD
Stenmark, H
机构：
[1] Norwegian Radium Hosp, Inst Canc Res, Dept Biochem, N-0310 Oslo, Norway
[2] Univ Calif San Diego, Sch Med, Div Cellular & Mol Med, La Jolla, CA 92993 USA
[3] Howard Hughes Med Inst, La Jolla, CA 92993 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 04期
关键词：
D O I：
10.1016/S0955-0674(00)00240-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane trafficking, Recently, phosphoinositides have been found to direct the localization and activity of effector proteins containing consensus sequence motifs such as FYVE, PH and ENTH domains. In addition, recent results show that regulated synthesis and turnover of phosphoinositides by membrane-associated phosphoinoside kinases and phosphatases spatially restrict the location of effecters critical for cellular transport processes, such as clathrin-mediated endocytosis, autophagy, phagocytosis, macropinocytosis and biosynthetic trafficking.
引用
收藏
页码：485 / 492
页数：8
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