Chiral Lewis acid catalysis in aqueous media. Catalytic asymmetric aldol reactions of silyl enol ethers with aldehydes in a protic solvent including water

被引:60
作者
Kobayashi, S [1 ]
Nagayama, S
Busujima, T
机构
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[2] Japan Sci & Technol Corp, CREST, Bunkyo Ku, Tokyo 1130033, Japan
[3] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1628601, Japan
关键词
D O I
10.1246/cl.1999.71
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Chiral copper(II)-catalyzed asymmetric aldol reactions of silyl enol ethers with aldehydes have been successfully carried out in a water-ethanol solution. The use of the protic solvent including water is essential in these reactions, and this report has proposed and demonstrated a new concept for solvents in catalytic asymmetric aldol reactions.
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页码:71 / 72
页数:2
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