The ins and outs of Wingless signaling

被引：72

作者：

Seto, ES

Bellen, HJ ^{[1
]}

机构：

[1] Baylor Coll Med, Div Neurosci, Dept Mol & Human Genet, Program Dev Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Div Neurosci, Dept Mol & Human Genet, Howard Hughes Med Inst, Houston, TX 77030 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.tcb.2003.11.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Signaling through the highly conserved Wingless/Wnt pathway plays a crucial role in a diverse array of developmental processes, many of which depend upon the precise regulation of Wingless/Wnt signaling levels. Recent evidence has indicated that the intracellular trafficking of Wingless/Wnt signaling components can result in significant changes in the level of signaling. Here, we examine three mechanisms through which intracellular trafficking might regulate Wingless signaling - the degradation of Wingless, its transport and the transduction of its signal. The intracellular trafficking of several Wingless/Wnt signaling components, including LRP5, LRP6, Dishevelled and Axin, as well as the functional implications of protein localization on Wingless/Wnt signaling, will be discussed.

引用

页码：45 / 53

页数：9

共 70 条

[61] DISTRIBUTION OF THE WINGLESS GENE-PRODUCT IN DROSOPHILA EMBRYOS - A PROTEIN INVOLVED IN CELL-CELL COMMUNICATION [J].