The emerging role of lysophosphatidic acid in cancer

被引：967

作者：

Mills, GB

Moolenaar, WH

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 08期

关键词：

D O I：

10.1038/nrc1143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

引用

收藏

页码：582 / 591

页数：10

相关论文

共 129 条

[1] Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein [J].

Altun-Gultekin, ZF ;

Chandriani, S ;

Bougeret, C ;

Ishizaki, T ;

Narumiya, S ;

de Graaf, P ;

Henegouwen, PVE ;

Hanafusa, H ;

Wagner, JA ;

Birge, RB .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) :3044-3058

[2] Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction [J].

Amerongen, GPV ;

Vermeer, MA ;

van Hinsbergh, VWM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (12) :E127-E133

[3] Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid [J].

An, SZ ;

Bleu, T ;

Hallmark, OG ;

Goetzl, EJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :7906-7910

[4] Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid [J].

An, SZ ;

Dickens, MA ;

Bleu, T ;

Hallmark, OG ;

Goetzl, EJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 231 (03) :619-622

[5] Malignant effusions and immunogenic tumour-derived exosomes [J].

Andre, F ;

Schartz, NEC ;

Movassagh, M ;

Flament, C ;

Pautier, P ;

Morice, P ;

Pomel, C ;

Lhomme, C ;

Escudier, B ;

Le Chevalier, T ;

Tursz, T ;

Amigorena, S ;

Raposo, G ;

Angevin, E ;

Zitvogel, L .

LANCET, 2002, 360 (9329) :295-305

[6] Serum lysophosphatidic acid is produced through diverse phospholipase pathways [J].

Aoki, J ;

Taira, A ;

Takanezawa, Y ;

Kishi, Y ;

Hama, K ;

Kishimoto, T ;

Mizuno, K ;

Saku, K ;

Taguchi, R ;

Arai, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (50) :48737-48744

[7]

Bachner D, 1998, DEV DYNAM, V213, P398

[8] Plasma lysophosphatidic acid concentration and ovarian cancer [J].

Baker, DL ;

Morrison, P ;

Miller, B ;

Riely, CA ;

Tolley, B ;

Westermann, AM ;

Bonfrer, JMG ;

Bais, E ;

Moolenaar, WH ;

Tigyi, G .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (23) :3081-3082

[9] Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo [J].

Balazs, L ;

Okolicany, J ;

Ferrebee, M ;

Tolley, B ;

Tigyi, G .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (02) :R466-R472

[10] Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid [J].

Bandoh, K ;

Aoki, J ;

Hosono, H ;

Kobayashi, S ;

Kobayashi, T ;

Murakami-Murofushi, K ;

Tsujimoto, M ;

Arai, H ;

Inoue, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) :27776-27785

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