The emerging role of lysophosphatidic acid in cancer

被引：967

作者：

Mills, GB

Moolenaar, WH

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 08期

关键词：

D O I：

10.1038/nrc1143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

引用

收藏

页码：582 / 591

页数：10

相关论文

共 129 条

[31]

Furui T, 1999, CLIN CANCER RES, V5, P4308

[32] IDENTIFICATION OF THE MOLECULAR-SPECIES OF LYSOPHOSPHATIDIC ACID PRODUCED WHEN PLATELETS ARE STIMULATED BY THROMBIN [J].

GERRARD, JM ;

ROBINSON, P .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1001 (03) :282-285

[33] The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site [J].

Gijsbers, R ;

Aoki, J ;

Arai, H ;

Bollen, M .

FEBS LETTERS, 2003, 538 (1-3) :60-64

[34]

Ginestra A, 1999, ANTICANCER RES, V19, P3439

[35] Gelsolin finding and cellular presentation of lysophosphatidic acid [J].

Goetzl, EJ ;

Lee, H ;

Azuma, T ;

Stossel, TP ;

Turck, CW ;

Karliner, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14573-14578

[36]

Goetzl EJ, 1999, CANCER RES, V59, P5370

[37] TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells [J].

Gschwind, A ;

Hart, S ;

Fischer, OM ;

Ullrich, A .

EMBO JOURNAL, 2003, 22 (10) :2411-2421

[38] Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors [J].

Hama, K ;

Bandoh, K ;

Kakehi, Y ;

Aoki, J ;

Arai, H .

FEBS LETTERS, 2002, 523 (1-3) :187-192

[39] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

[40] Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor [J].

Hasegawa, Y ;

Erickson, JR ;

Goddard, GJ ;

Yu, SX ;

Liu, SY ;

Cheng, KW ;

Eder, A ;

Bandoh, K ;

Aoki, J ;

Jarosz, R ;

Schrier, AD ;

Lynch, KR ;

Mills, GB ;

Fang, XJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (14) :11962-11969

← 1 2 3 4 5 6 7 8 9 10 →