共 49 条
In Vitro and in Vivo Studies of FePt Nanoparticles for Dual Modal CT/MRI Molecular Imaging
被引:303
作者:

Chou, Shang-Wei
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Natl Taiwan Normal Univ, Dept Chem, Taipei 11677, Taiwan Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan

Shau, Yu-Hong
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Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan
Natl Cheng Kung Univ, Dept Stomatol, Tainan 70101, Taiwan Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan

Wu, Ping-Ching
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Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan
Natl Cheng Kung Univ, Dept Stomatol, Tainan 70101, Taiwan
Natl Cheng Kung Univ, Inst Basic Med Sci, Tainan 70101, Taiwan Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan

Yang, Yu-Sang
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Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan
Natl Cheng Kung Univ, Dept Stomatol, Tainan 70101, Taiwan
Natl Cheng Kung Univ, Inst Basic Med Sci, Tainan 70101, Taiwan Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan

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Chen, Chia-Chun
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机构:
Natl Taiwan Normal Univ, Dept Chem, Taipei 11677, Taiwan
Acad Sinica, Inst Atom & Mol Sci, Taipei 10617, Taiwan Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan
机构:
[1] Natl Cheng Kung Univ, Inst Oral Med, Tainan 70101, Taiwan
[2] Natl Cheng Kung Univ, Dept Stomatol, Tainan 70101, Taiwan
[3] Natl Taiwan Normal Univ, Dept Chem, Taipei 11677, Taiwan
[4] Natl Cheng Kung Univ, Inst Basic Med Sci, Tainan 70101, Taiwan
[5] Natl Cheng Kung Univ, Adv Optoelect Technol Ctr, Tainan 70101, Taiwan
[6] Natl Cheng Kung Univ, Ctr Micro Nano Sci & Technol, Tainan 70101, Taiwan
[7] Acad Sinica, Inst Atom & Mol Sci, Taipei 10617, Taiwan
关键词:
IRON-OXIDE NANOPARTICLES;
RAY COMPUTED-TOMOGRAPHY;
COATED GOLD NANOPARTICLES;
MRI CONTRAST AGENTS;
MAGNETIC NANOPARTICLES;
SIZE;
CANCER;
NANOCRYSTALS;
RELAXIVITY;
DELIVERY;
D O I:
10.1021/ja1035013
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
The water-solvable FePt nanoparticles of 3, 6, and 12 nm in diameter (3 nm-, 6 nm-, and 12 nm-FePt) were synthesized and applied as a dual modality contrast agent for CT/MRI molecular imaging. These nanoparticles present excellent biocompatibility and hemocompatibility in all test concentrations for the imaging contrast. The biodistribution analysis revealed the highest serum concentration and circulation half-life for 12 nm-FePt, followed by 6 nm-FePt then 3 nm-FePt. Thus, the 3 nm-FePt showed higher brain concentrations. Anti-Her2 antibody conjugated FePt nanoparticles demonstrated molecular expression dependent CT/MRI dual imaging contrast effect in MBT2 cell line and its Her2/neu gene knock out counterpart. Selective contrast enhancement of Her2/neu overexpression cancer lesions in both CT and MRI was found in tumor bearing animal after tail vein injection of the nanoparticles. The 12 nm-FePt outperformed 3 nm-FePt in both imaging modalities. These results indicate the potential of FePt nanoparticles to serve as novel multimodal molecular imaging contrast agents in clinical settings.
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页码:13270 / 13278
页数:9
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