Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging

被引：409

作者：

Alric, Christophe ^{[1
]}

Taleb, Jacqueline ^{[2
]}

Le Duc, Geraldine ^{[3
]}

Mandon, Celine ^{[2
]}

Billotey, Claire ^{[2
]}

Le Meur-Herland, Alice ^{[2
]}

Brochard, Thierry ^{[3
]}

Vocanson, Francis ^{[5
]}

Janier, Marc ^{[2
]}

Perriat, Pascal ^{[4
]}

Roux, Stephane ^{[1
]}

Tillement, Olivier ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5620, Lab Phys Chim Mat Luminescents, F-69622 Villeurbanne, France

[2] Univ Lyon 1, CNRS, UMR 5515, Lab CREATIS Animage,INSA Lyon, F-69622 Villeurbanne, France

[3] European Synchrotron Radiat Facil, Polygone Sci Louis Neel, ID Biomed Beamline 17, F-38000 Grenoble, France

[4] INSA Lyon, CNRS, UMR 5510, F-69621 Villeurbanne, France

[5] Univ St Etienne, Lab Hubert Curien, UMR 5516, CNRS, F-42000 St Etienne, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 18期

关键词：

D O I：

10.1021/ja078176p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell, whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in the lungs, spleen, and liver.

引用

页码：5908 / 5915

页数：8

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