Bisphosphonates:: Synthesis, chemical analysis and pharmacological applications

被引:16
作者
Fernandes, C [1 ]
Leite, RS [1 ]
Lanças, FM [1 ]
机构
[1] Univ Sao Paulo, Dept Quim & Fis Mol, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
来源
QUIMICA NOVA | 2005年 / 28卷 / 02期
关键词
bisphosphonates; bone diseases; high performance liquid chromatography;
D O I
10.1590/S0100-40422005000200019
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
BISPHOSPHONATES: SYNTHESIS, CHEMICAL ANALYSIS AND PHARMACOLOGICAL APPLICATIONS. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Various synthetic routes to prepare different types of bisphosphonates have been described, with distinct potency and pharmacological activity. A number of analytical techniques are currently being used to analyze these drugs; among these, the high performance liquid chromatography (HPLC), with different systems of detection, is worth highlighting. However, the development of more sensitive methods is still necessary, once they are essential for bioavailability and bioequivalence studies. This paper reports the major synthesis routes, chemical analysis methodologies and pharmacological applications of bisphosphonates.
引用
收藏
页码:274 / 280
页数:7
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